Detection and application of bladder cancer specific proteins

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Kitasato University
• Principal Investigator: Matsumoto Kazumasa 北里大学, 医学部, 准教授 (70306603)
• Co-Investigator(Kenkyū-buntansha): 岩村 正嗣 北里大学, 医学部, 教授 (20176564) ; 佐藤 雄一 北里大学, 医療系研究科, 研究員 (30178793)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 膀胱癌 / 蛋白解析 / 腫瘍マーカー

Outline of Final Research Achievements

The purpose of this study is to identify proteins that are specifically expressed in bladder cancer and to apply them to diagnostic markers. During the study period, we have identified tumor-associated proteins and autoantibodies that characteristically increase or decrease in bladder cancer using tissues, serum, and urine of bladder cancer patients. Seven bladder cancer-related proteins were identified and correlated with existing protein expression in bladder cancer, compared with clinicopathological findings and prognosis, and compared with the effect of chemotherapy treatment. We were also able to compare the results with those of chemotherapy. We have also applied for a patent for some of the results. In the future, we plan to further examine the proteins obtained in this study, attempt to develop a kit, and aim to apply it to actual clinical practice.

Free Research Field

泌尿器科学

Academic Significance and Societal Importance of the Research Achievements

腫瘍関連の特異的蛋白質を特定することは、膀胱癌のみならず、様々な癌腫において次世代に向けた診断・治療における医療躍進の重要な課題となっている。早期発見・早期治療ならびに個別治療アルゴリズムは、医療費削減の最も有効な方法であり、本研究の遂行は、現在進行しているがんゲノム医療を含む個別医療体制確立にとって大きな意義があると思われる。さらに、有効な腫瘍マーカーの存在しない膀胱癌関連領域の発展に一石を投じるものと考えている。