2023 Fiscal Year Final Research Report
Establishment of a new preventive method to correct gut microbiota in infants with recurrent urinary tract infections
| Project/Area Number |
21K09361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56030:Urology-related
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 小児 / 乳幼児 / 尿路感染症 / 膀胱尿管逆流 / 腸内細菌叢 / プロバイオティクス / プレバイオティクス / シンバイオティクス |
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| Outline of Final Research Achievements |
We found that the intestinal microbiota of infants with febrile urinary tract infection (fUTI) was rich in Escherichia-Shigella species, including E. coli, and significantly low in Bacteroides fragilis, which suppresses inflammatory cytokines. In addition, the intake of dietary fiber-rich functional barley increased beneficial bacteria such as butyric acid bacteria in the intestinal microbiota, suggesting that dietary fiber intake may correct the intestinal microbiota. However, when synbiotics were used to prevent fUTI in infants with VUR, five out of six cases recurred. Therefore, in order to target the intestinal microbiota as a therapeutic target, the causal relationship between the intestinal microbiota and fUTI needs to be further elucidated.
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| Free Research Field |
腎泌尿器
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| Academic Significance and Societal Importance of the Research Achievements |
先天性腎尿路異常がない有熱性尿路感染症（fUTI）を発症した乳幼児の腸内細菌叢の解析で、大腸菌を含むEscherichia-Shigella属が多く、炎症性サイトカインを抑制するBacteroides fragilisの割合が有意に低いことを示した。したがって腸内細菌叢の異常が、fUTIの発症リスク因子になることを明らかにした。また、食物繊維が豊富な機能性大麦を摂取することで、腸内細菌叢の酪酸酸性菌などの有益菌を増加させたことから、食物繊維の摂取は腸内細菌叢を是正する可能性があることを示した。さらなる検討が必要であるが、fUTIの再発予防に腸内細菌叢の是正を治療の標的にできる可能性がある。
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