Research on the relationship between the pathology of interstitial cystitis and the immune response by regulatory T cells

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09395
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Nagoya University
• Principal Investigator: Ishida Shohei 名古屋大学, 医学部附属病院, 講師 (90744029)
• Co-Investigator(Kenkyū-buntansha): 松川 宜久 名古屋大学, 医学系研究科, 准教授 (30378145)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 間質性膀胱炎

Outline of Final Research Achievements

With the aim of elucidating the pathogenesis of interstitial cystitis and exploring the possibility of new treatments, we investigated the relationship of immune responses in the pathogenesis of interstitial cystitis. Furthermore, we analyzed the urinary bacterial flora and urinary metabolome, which may affect the immune response (regulatory T cell expression) in the bladder, and elucidated the factors that cause and exacerbate interstitial cystitis. The results showed that the proportion of Foxp3-positive T cells tended to be higher in patients with interstitial cystitis compared to normal patients (control) and bladder pain syndrome (non-Hanner type) group (BPS group). , no significant results were obtained. We also performed urinary proteomics and metabolome analysis, but were unable to identify specific urinary metabolites or proteins.

Free Research Field

泌尿器科学関連

Academic Significance and Societal Importance of the Research Achievements

間質性膀胱炎は、膀胱の非特異的な慢性炎症により頻尿・尿意亢進・尿意切迫感・膀胱痛などの症状を呈する疾患で、国の難病指定に登録されているが、その病因については明らかになっておらず、治療についても根治が期待できる治療法はなく、その病態の解明は、新規治療の開発につながる。今回の研究では有意差はでなかったものの、免疫応答の点から制御性T細胞の発現について着目したところ、間質性膀胱炎患者ではFoxp3陽性T細胞の割合が高い傾向があり、さらにこれも結果がでなかったものの尿中細菌叢との関連も示唆する所見は見られたため、新規治療の開発につながる可能性は見いだせたと思われた。