2023 Fiscal Year Final Research Report
Research on improving fertility by Lf and Tregs
| Project/Area Number |
21K09449
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | 制御性T細胞 / ラクトフェリン / 常在細菌叢 / 胚着床 / Lactorerrin / Treg |
|---|
| Outline of Final Research Achievements |
Regulatory T cells (Tregs) are known to be seen in large numbers in the uterine mucosa during the implantation and pregnancy period, which suggesting the importance of Tregs for maintain the pregnancy. On the other hand, lactoferrin (Lf) has various immunostimulatory effects, especially, Lf increases the development rate of early embryos. Based on these facts, I investigated the effect of Lf on Treg activity in the uterine mucosa during the implantation period.As a result, Lf administration slightly increased the number of Tregs in the uterine mucosa during implantation period. However, there was no obvious difference between the LF group and control group.
These results could be suggesting that Tregs may not be involved in embryo implantation as previously reported.
|
| Free Research Field |
粘膜免疫
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究結果は現在社会問題となっている不妊の原因の解明やその治療に対して寄与するものである。過去の報告から、Tregは着床時および妊娠中の子宮粘膜において多数認められたことから、妊娠の維持に関与するとの考察が為されている。今回の実験はこれを踏まえて行われ、Lf投与群ではTregの数が増加する傾向が見られたが、Lf未投与の個体においても、そもそも報告にあるようなTregの着床期子宮粘膜における大幅な増加が認められなかったため、両群間で定量的な相違を示すことが出来なかった。このことから、妊娠期におけるTregの関与について、今後更なる詳細な検討を行い、研究を進める必要がある。
|
