Metabolome analysis for Early and Late onset hypertension disorders of pregnancy

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09473
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Kyozuka Hyo 福島県立医科大学, 医学部, 博士研究員 (00644113)
• Co-Investigator(Kenkyū-buntansha): 山口 明子 福島県立医科大学, 医学部, 講師 (00457764) ; 安田 俊 福島県立医科大学, 医学部, 講師 (50566817) ; 藤森 敬也 福島県立医科大学, 医学部, 教授 (80285030)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 妊娠高血圧症候群 / メタボローム解析 / バイオマーカー / プレコンセプションケア / 予防医療

Outline of Final Research Achievements

Late-onset preeclampsia (Lo-PE) is characterized by the onset of hypertension with organ damage after 34 weeks of pregnancy. Identifying the mechanisms behind Lo-PE is crucial for prevention before symptoms appear. This study aimed to identify first-trimester maternal serum metabolites associated with Lo-PE using targeted metabolomic analysis. Conducted at Fukushima Regional Center as part of the Japan Environment and Children Study, it involved 12 patients with Lo-PE and 12 matched controls. Capillary electrophoresis-mass spectrometry was used to analyze charged metabolites in first-trimester serum samples, identifying 183 metabolites. Results showed significantly higher glucosamine and lower serotonin levels in Lo-PE patients compared to controls. While the exact mechanism of Lo-PE remains unclear, early pregnancy nutrition and serotonin levels, reflecting pre-pregnancy diet and mental health, are crucial. Preconception care may help prevent Lo-PE onset.

Free Research Field

周産期医学

Academic Significance and Societal Importance of the Research Achievements

Lo-PEの発症には様々な環境要因の関与が示唆されているが、正確なメカニズムは未解明である。今回の研究成果を介して妊娠初期の栄養摂取と、妊娠前の食生活や精神的健康を反映するセロトニン状態がLo-PE発症に関与している可能性があり、Lo-PE発症予防には、妊娠前の食事状態や精神健康状態を管理するプレコンセプションケアが重要となる可能性がある。