2023 Fiscal Year Final Research Report
Induction of cancer stem cell phenotype using hydrogel and discovery of new therapeutic targets
| Project/Area Number |
21K09485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 卵巣がん幹細胞 / ハイドロゲル |
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| Outline of Final Research Achievements |
Two-dimensional culture using hydrogel enabled the induction of ovarian cancer stem cells. Cells obtained by hydrogel induction exhibited stem cell characteristics, with high expression of stem cell biomarkers, high anticancer drug resistance, and dependence on mitochondrial metabolism observed. Furthermore, in vivo experiments showed that these cells exhibited stronger tumorigenic potential. From microarray analysis, we identified a gene X that is highly expressed specifically in ovarian cancer stem cells. This has not been reported in previous studies, and inhibitory therapy targeting gene X could be a new potential therapy for ovarian cancer.
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| Free Research Field |
婦人科腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
がん幹細胞を標的とする効果的な治療法を開発するためには、がん幹細胞の特性を詳細に解明することが不可欠である。その手段の一つとして、本研究で示された卵巣癌幹細胞の誘導法を用いること、その細胞内シグナル伝達や遺伝子発現に関する詳細な解析を行うことで、今後の難治性卵巣癌の新規治療法の開発に繋がることが期待される。したがって、今後の卵巣癌の治療成績向上に資する可能性のある研究であり、学術的並びに社会的意義が高い研究成果が得られたと考えている。
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