Study for reproductive regulatory mechanisms centered on kisspeptin

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09516
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Shimane University
• Principal Investigator: ORIDE AKI 島根大学, 学術研究院医学・看護学系, 講師 (00423278)
• Co-Investigator(Kenkyū-buntansha): 金崎 春彦 島根大学, 学術研究院医学・看護学系, 准教授 (10325053)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: キスペプチン / 視床下部 / 下垂体 / 卵巣

Outline of Final Research Achievements

Anti-Mullerian duct hormone (AMH), which is produced by ovarian granulosa cells, is also expressed in the hypothalamus. AMH increased GnRH expression and had inhibitory effects on kisspeptin expression in the negative feedback center, KNDy neurons. Furthermore, administration of sex steroid hormones to rats whose ovaries had been removed and in which the negative feedback mechanism was active induced characteristic changes in the pituitary gland. In the experiment using granulosa cells of human follicles, E2 levels differed significantly depending on follicle size, but not on Kiss-1 or Kiss-1 receptor gene expression.

Free Research Field

生殖内分泌

Academic Significance and Societal Importance of the Research Achievements

視床下部-下垂体ー性腺軸におけるキスペプチンの作用とその制御機構の一端を解明することができた。