Proposal of new diagnosis, treatment, prevention approach for endometrial cancer targeting estrogen-mediated pathway

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09523
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Mori Taisuke 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00569824)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 子宮体癌

Outline of Final Research Achievements

To clarify (1) the effects of estrogen-related receptors on estrogen response and drug sensitivity in uterine endometrial cancer, and (2) the relationship between estrogen-related receptors and metabolic abnormalities in the cancer.
No correlation was found between ERRs and estrogen receptor (ERR) expression levels. The ERRs enhances the expression of estrogen biosynthetic enzymes, suggesting an effect on estrogen signaling. We performed a metabolomic analysis of the association between estrogen-related receptors and metabolic abnormalities in cancer. X was obtained as a chemotherapy resistance factor; X is overexpressed in uterine cancer cells and associated with prognosis. We also found that X is associated with platinum sensitivity in a low nutritional environment.

Free Research Field

婦人科腫瘍学

Academic Significance and Societal Importance of the Research Achievements

これまで研究者らは、エストロゲン関連受容体が子宮体癌進展メカニズムに重要な因子であることを示してきた。本研究では、ERRがエストロゲン応答性に及ぼす影響を検証することで、エストロゲン伝達経路をターゲットとした治療戦略の分子基盤を確立させた。治療抵抗性因子を同定しえたため、この系についての検証を進めている。