2023 Fiscal Year Final Research Report

Development of a classification method for uterine adenomyosis based on gene expression profiles

Research Project

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Project/Area Number	21K09547
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Nara Medical University
Principal Investigator	Kana Iwai 奈良県立医科大学, 医学部, 助教 (60588531)
Co-Investigator(Kenkyū-buntansha)	山田有紀奈良県立医科大学, 医学部, 助教 (20588537) 松原翔奈良県立医科大学, 医学部附属病院, 研究員 (20825236) 川口龍二奈良県立医科大学, 医学部, 准教授 (50382289)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	子宮腺筋腫 / 1型子宮腺筋症 / 2型子宮腺筋症 / KRAS変異 / 酸化ストレス
Outline of Final Research Achievements	Uterine adenomyosis is a disease that causes excessive menstruation, dysmenorrhea, and infertility, and significantly reduces women's quality of life. In this study, two histological classification types were examined. Compared to type 1 adenomyosis, type 2 adenomyosis was associated with significantly more ovarian endometriotic cysts, deep endometriosis, and peritoneal endometriosis lesions. In addition, KRAS mutant proteins associated with KRAS mutations were detected in all classification types and their normal endometrium. Oxidative stress in endometrial tissues of endometrium with KRAS mutations and adenomyosis was comparable regardless of site.
Free Research Field	産婦人科学
Academic Significance and Societal Importance of the Research Achievements	子宮腺筋症を発症機序の異なる分類型に分けることは、および機序解明のために有用であることが明らかとなった。今後の症例蓄積によって、子宮腺筋症により生じ得る臨床症状に対する治療や、発症前の予防につながる可能性がある。また、今回一部が明らかとなった子宮腺筋症の発症機序の全容は依然として不明であり、解明を進めることは、治療介入すべき時期の選択や新規の治療戦略の開発につながり、女性のQOL向上や他の女性特有の患の誘発を未然に防ぐことが可能になると考える。