2023 Fiscal Year Final Research Report
The study of New cell eeath in eosinophilic inflammation
| Project/Area Number |
21K09563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56050:Otorhinolaryngology-related
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
Ohta Nobuo 東北医科薬科大学, 医学部, 教授 (20282212)
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| Co-Investigator(Kenkyū-buntansha) |
太田 裕子 羽陽学園短期大学, 幼児教育科, 非常勤講師 (40442016)
佐藤 輝幸 東北医科薬科大学, 医学部, 講師 (30400493)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 好酸球性副鼻腔炎 / 好酸球性中耳炎 / EETOSIS / DNA traps / ぺリオスチン |
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| Outline of Final Research Achievements |
In EOM, ETosis-derived DNA traps/cytolytic Eo are common feature and major structural components within the middle ear effusions. These findings may allow us to speculate that excess formation of extracellular DNA traps might contribute to the increased viscosity of the middle ear effusions and potential therapeutic target.
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| Free Research Field |
耳鼻咽喉科
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| Academic Significance and Societal Importance of the Research Achievements |
ETosisによって生じるDNA trapsの好酸球性炎症疾患における存在や、その性状について検討を加える予定である。ETosisに関与する分子を明確にすることで、関与する分子を標的とした治療方法の独創的で新規性のある治療戦略の展開が期待される。
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