Role of CD271 in hypopharyngeal cancer

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09621
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Imai Takayuki 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 特任研究員 (80408583)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 下咽頭癌

Outline of Final Research Achievements

We have previously discovered CD271 as a cancer stem cell marker for hypopharyngeal cancer and demonstrated that targeting CD271-positive cells can achieve tumor suppression in vivo. In this project, we will identify CD271-related cancer-specific proliferation pathways and establish the responsible factors and pathways to apply as a new therapeutic target for hypopharyngeal cancer. As a result, we identified two new responsible factors.

Free Research Field

がん生物学

Academic Significance and Societal Importance of the Research Achievements

下咽頭癌はその機能的重要性も相まって治療困難な癌種である。私たちは新しい治療標的を探るために、CD271という分子に着目して研究を実施してきた。CD271は下咽頭癌の増殖に重要であることがわかっていたが、本課題ではその下流分子の同定に成功した。今後も知見を重ね、下流分子の阻害剤を開発していく。