2023 Fiscal Year Final Research Report
Development of a non-invasive diagnostic method for diabetes-related periodontitis using sclerostin as a novel target bio-marker
| Project/Area Number |
21K09874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木戸 淳一 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 (10195315)
板東 美香 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (10510000)
生田 貴久 徳島大学, 大学院医歯薬学研究部(歯学域), 助教 (00746563)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 糖尿病関連歯周炎 / スクレロスチン / 歯肉溝滲出液 / AGEs |
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| Outline of Final Research Achievements |
This research focused on sclerostin (SOST) as a biomarker in gingival crevicular fluid that can be collected non-invasively from patients, and investigated its association with the clinical severities of periodontitis and diabetes.
In addition, the correlations between levels of SOST and of AGEs, and between levels of SOST and of periodontal pathogenic bacteria were also analyzed. As a result, no significant differences in SOST levels were found among the three groups of patients with diabetes-related periodontitis, patients with non-diabetic periodontitis, and healthy controls. Furthermore, no correlation was found between levels of AGEs and of SOST, or between levels of SOST and PISA.
These results show that it is difficult to diagnose diabetes-related periodontitis using SOST alone. The correlation between level of SOST and age suggests that the level of SOST in GCF is influenced by factors other than severities of diabetes and periodontitis.
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| Free Research Field |
歯周病学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は糖尿病関連歯周炎の新規バイオマーカーとしてSOSTに着目し、患者の歯肉溝滲出液のSOST量を測定した。そして糖尿病合併症の原因の１つである最終糖化産物やP. gingivalis等の歯周病原細菌を測定して、SOSTとこれらの数値、SOSTと歯周病や糖尿病の重症度との関連性を解析した。本研究では、糖尿病関連歯周炎の重症度のクラス分けや進行予測を行う際に、歯周炎局所のSOSTのみを用いて糖尿病関連歯周炎を診断するのは困難と判断された。症例数をさらに増やして解析することが求められるとともに、糖尿病関連歯周炎患者のバイオマーカーとしてSOST以外の別の物質を探索する必要性が示唆された。
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