Application of novel calcium phosphate cement in curative treatment of dentin hypersensitivity

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09879
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Nihon University
• Principal Investigator: HAYASHI Makoto 日本大学, 歯学部, 教授 (00301557)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: リン酸カルシウムセメント / 象牙質知覚過敏症

Outline of Final Research Achievements

Dentin hypersensitivity (DHS) is one of the most encountered conditions in dental practice. Its mechanism involves the movement of fluid within the dentin tubules exposed in the oral cavity due to stimulation, which excites the free nerve endings and causes pain. Therefore, treatment generally involves sealing the dentin tubules with various materials; however, clinically satisfactory materials are not yet widespread.
Calcium phosphate cement (CPC) is a highly biocompatible cement that generates hydroxyapatite and is also used as a bone graft material. In this study, we improved the conventional CPC and developed a novel CPC characterized by a mono-modal particle distribution, which indicates solid-solution of α-tricalcium phosphate-tetracalcium phosphate. This novel CPC was suggested to be usable as a treatment material for DHS.

Free Research Field

歯科保存学

Academic Significance and Societal Importance of the Research Achievements

超高齢社会に入った現在，様々な口腔保健に関する施策・普及活動よって口腔衛生状態が改善され，高齢者を含めて残存歯数が増加している。そのため，歯肉退縮による歯根面の露出や咬耗・摩耗による象牙質の露出により，象牙質知覚過敏症（DHS）が高頻度で発症している。しかしながら，DHS抑制材などを利用した治癒率は60～70％程度であり，効果の持続時間が短い，痛みが再発する可能性が高いなどの報告もあり，臨床的に満足のできる材料が普及していない。
本研究では従来からのリン酸カルシウムセメント（CPC）の構成成分を変化させた新規 CPCを試作し，DHS抑制材として実用化の一助となる基礎的データを取得した。