2023 Fiscal Year Final Research Report
The prevalence and progression of dental erosion in patients with gastroesophageal reflux disease (GERD)
| Project/Area Number |
21K09889
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Kitasako Yuichi 東京医科歯科大学, 歯学部, 非常勤講師 (30361702)
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| Co-Investigator(Kenkyū-buntansha) |
岩切 勝彦 日本医科大学, 大学院医学研究科, 大学院教授 (50221099)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 胃食道逆流症疾患 / GERD / 酸蝕症 / 唾液 / 医科歯科連携 |
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| Outline of Final Research Achievements |
The prevalence between Dental Erosion (DE) in association with reflux esophagitis (RE) has been reported. However, the severity of both diseases and the relationship between DE and non-erosive reflux disease (NERD) is unclear. In this case-control study, the prevalence and severity of DE were investigated in RE, NERD and healthy controls. There was a significant association of the prevalence and severity between RE and DE, while there was no significant correlation between the prevalence of NERD and DE. Clinical signs such as the erosive tooth wear were depended on the severity of RE. Moreover, the factors associated with the prevalence of DE in patients with RE and factors associated with severity of DE were also evaluated. Saliva secretion, severity of RE and Proton pump inhibitor resistance were associated with the prevalence of DE, while age, BMI, and severity of RE were associated with the severity of DE. Lower saliva secretion and BMI were significant factors for DE.
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| Free Research Field |
歯科保存学分野
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| Academic Significance and Societal Importance of the Research Achievements |
胃食道逆流症は、逆流性食道炎（RE）と非びらん性逆流性食道炎（NERD）に鑑別される。胃食道逆流症と歯の酸蝕症（DE）との関連性は不明であるが、その要因としてREとNERDを混合してDEと比較していたことが挙げられる。そこで本研究では、医科歯科連携のもと、REとNERDの鑑別を行いDEとの関連性を検討した結果、NERDでは明確な関連性を認めなかったものの、REとDEとの間に関連性を認めた。また、REが重症化するとDEも重症化することが判明した。さらに、REにおけるDEリスク因子として唾液分泌量、RE重症度および薬剤抵抗性が、DE重症化リスク因子として年齢、BMIおよびRE重症度が挙げられた。
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