Basic research to investigate the involvement of advanced glycation endproducts in the progression and exacerbate of periodontal disease in diabetes mellitus

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K09901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Nihon University
• Principal Investigator: TANABE Natsuko 日本大学, 歯学部, 准教授 (10409097)
• Co-Investigator(Kenkyū-buntansha): 鈴木 直人 日本大学, 歯学部, 教授 (10226532)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 終末糖化産物 / 骨芽細胞 / 炎症性メディエーター

Outline of Final Research Achievements

AGEs are generated by the Maillard reaction between amino acids of proteins and reducing sugars such as glucose. They are produced and accumulated not only in foods but also in living organisms. In this study, we focused on the relationship between diabetes and periodontal disease, which is closely related to the generation of AGEs. We hypothesized that AGEs accumulated in the blood due to diabetes may be one of the factors affecting the exacerbation and refractoriness of periodontal disease in diabetic patients. The results showed that AGEs further exacerbate the inflammation promoted by the endotoxin LPS of Gram-negative bacteria, which are periodontal pathogens.

Free Research Field

口腔生化学

Academic Significance and Societal Importance of the Research Achievements

本研究は，AGEsが骨芽細胞でLPSによって誘導された炎症を増悪することをIL-1alpha、プロスタグランジンE2ならびにS100A9などの炎症性メディエーター発現の促進と促進するための分子制御機構の１つを明らかにした。これらの本研究成果は，高血糖状態によって生成されたAGEsが，歯周病での歯槽骨吸収の原因の１つであるLPSによる炎症を増悪させること，さらにその機構が明らかとなることによって，将来的に歯周病の治療や予防へ役立てる一考になると考える。