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2023 Fiscal Year Final Research Report

Small compounds driven direct conversion of functional human MSC

Research Project

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Project/Area Number 21K09937
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57040:Regenerative dentistry and dental engineering-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Yamamoto Kenta  京都府立医科大学, 医学(系)研究科(研究院), 助教 (00636160)

Co-Investigator(Kenkyū-buntansha) 松田 修  京都府立医科大学, 医学(系)研究科(研究院), 教授 (00271164)
岸田 綱郎  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00370205)
山本 俊郎  京都府立医科大学, 医学(系)研究科(研究院), 講師 (40347472)
Project Period (FY) 2021-04-01 – 2024-03-31
Keywords再生医療 / ダイレクト・リプログラミング / MSC
Outline of Final Research Achievements

We succeeded in inducing mesenchymal stem cell (MSC) phenotypes in somatic cells by culturing them with a specific combination of some chemical compounds under particular conditions. The resultant cells (cdMSCs) showed high levels of MSC’s marker expression, and were capable of differentiating into osteoblasts and adipocytes similarly to primary MSCs. Also, the cdMSCs displayed high migration ability and powerful anti-inflammatory function. These results may contribute to new regenerative dental medicine and give huge impact with regards to both scientific and practical implications.

Free Research Field

再生医療

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、従来の治療法では治療が困難であった歯科疾患への新規再生歯科治療確立のための基盤技術の提供を促すもので、治療後の患者のQOLとADLを大きく高める可能性がある。また歯科疾患のみならず多分野での再生治療にも大きく貢献できるものであり、その学術的・社会的意義は大きい。

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Published: 2025-01-30  

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