Elucidation of the mechanism of differentiation control of jaw bone marrow mesenchymal stem cells by regulating intracellular energy metabolism

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Kagoshima University
• Principal Investigator: ISHII Masakazu 鹿児島大学, 医歯学域歯学系, 助教 (00456683)
• Co-Investigator(Kenkyū-buntansha): 西村 正宏 鹿児島大学, 医歯学域歯学系, 教授 (00294570)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 間葉系幹細胞 / 脂肪分化 / 活性酸素種

Outline of Final Research Achievements

Mesenchymal stem cells (MSCs) are present in various tissues within the body and have the ability to differentiate into tissues such as bone, cartilage, and fat. It has been reported that MSCs present in different tissues exhibit distinct characteristics due to differences in their developmental origins. MSCs found in the maxillary/mandibular bone marrow (MBMSCs) have been shown to hardly differentiate into adipocytes, but the mechanism of adipogenic differentiation suppression in MBMSCs has not been fully elucidated. This study revealed that the suppression of ROS production derived from NOX4 during adipogenic induction might lead to a decrease in the adipogenic differentiation potential of MBMSCs.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

本研究によって、脂肪分化誘導によるNOX4由来のROS産生増加の抑制がMBMSCの脂肪分化能の低下を引き起こす可能性があることが明らかになり、MBMSCの組織特異的な特性を解明するための重要な手がかりとなった。従って、本研究は学術的・社会的意義の高いものである。