Study for investigating mechanisms of mandibular development

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Ishida Yoko 新潟大学, 医歯学系, 特任准教授 (10377187)
• Co-Investigator(Kenkyū-buntansha): 前田 健康 新潟大学, 医歯学系, 教授 (40183941) ; 大峡 淳 新潟大学, 医歯学系, 教授 (40266169) ; 川崎 勝盛 新潟大学, 医歯学系, 助教 (40529640)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 発生 / 先天異常 / 小下顎症 / 下顎骨

Outline of Final Research Achievements

It is known that one-third of all congenital anomalies involve craniofacial abnormalities. Among them, micrognathia is one of the most frequent congenital anomalies. The present study suggest the possibility that it is caused by changes in Hh and Wnt signaling.

Free Research Field

歯学

Academic Significance and Societal Importance of the Research Achievements

多くの先天異常は顎顔面異常を伴う。本研究のように、その原因を究明できれば、子宮内の胎児の生前診断と生前治療へのアプローチ研究が可能となり、将来の先天異常による障害の軽減につながる。