Establishment of animal model of oral lichen planus and development of dopamine signal-regulated therapeutics

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10146
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Saitama Medical University
• Principal Investigator: Ko Ito 埼玉医科大学, 医学部, 准教授 (20419758)
• Co-Investigator(Kenkyū-buntansha): 川野 雅章 埼玉医科大学, 医学部, 准教授 (30447528) ; 佐藤 毅 埼玉医科大学, 医学部, 准教授 (60406494)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 口腔扁平苔癬 / ラット / TGF-beta

Outline of Final Research Achievements

Oral lichen planus (OLP), a chronic inflammatory lesion that develops on the oral mucosa and is mainly caused by neutrophilic inflammation, is often refractory because the pathogenesis is unknown; high salivary IL-8 levels have been reported in OLP, and cellular immunity has been implicated in its pathogenesis. In the present study, we used four IBD animal models of oxazolone, DSS, TNBS, and iodoacetamide as references to create animal models of OLP in which these drugs were applied to the oral mucosa; we compared clinical specimens obtained from OLP patients with the histology of each OLP animal model; the results showed that the OLP animal models were more sensitive to cytokines than the human specimens, and the OLP animal models were more sensitive to cytokines than the human specimens. We examined whether the profiles showed similar profiles compared to cytokine profiling in human specimens.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

本研究によって、口腔扁平苔癬の病態解明に役立つ成果を得ることができた。動物モデルの作製について、技術的な困難が存在することを示した。