The role of LIPUS in enhancement of bone remodeling during orthodontic tooth movement

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10154
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: Fukunaga Tomohiro 東北大学, 大学病院, 講師 (70362994)
• Co-Investigator(Kenkyū-buntansha): 溝口 到 東北大学, 歯学研究科, 教授 (20200032) ; 坂本 麻由里 東北大学, 大学病院, 医員 (20846422)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 歯の移動 / 骨改造 / 機械的刺激

Outline of Final Research Achievements

Orthodontic treatment often needs long duration, is associated with risks such as dental caries and periodontal diseases. Therefore, it is very important to shorten the duration of treatment by stimulating bone remodeling. LIPUS stimulation is a kind of non-invasive physical mechanical stress. In this study, the effects of mechanical stimulation on bone remodeling during experimental tooth movement were analyzed. When mechanical stimulation was applied to experimental tooth movement, the number of osteoclasts were significantly increased on the compression side of tooth movement compared with that of without mechanical stimulation, leading to the acceleration of orthodontic tooth movement. In addition, neural sodium voltage-gated channel beta subunit 3 may be associated with nociceptive transmission and regulate osteoclast activity in the periodontal ligament on the compression side of orthodontic tooth movement.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

矯正学的歯の移動時に生じる圧迫側および牽引側の組織学的変化を実験動物を用いて詳細に解析することにより、矯正学的歯の移動時に生じる骨改造機構の一端を解明することができた。さらに矯正学的歯の移動に機械的刺激を負荷すると、圧迫側における破骨細胞による骨吸収を促進することにより、歯の移動距離が増加することが明らかとなり、機械的刺激の負荷による矯正学的歯の移動の亢進の可能性が示唆された。これらの研究成果は、矯正学的歯の移動を促進する骨改造亢進機構の解明に繋がり、矯正歯科臨床に貢献できると考えられる。