Mechanisms of resin allergy and adjuvant effect

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10157
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: Bando Kanan 東北大学, 大学病院, 助教 (20772198)
• Co-Investigator(Kenkyū-buntansha): 黒石 智誠 東北大学, 歯学研究科, 講師 (30400261)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: アレルギー

Outline of Final Research Achievements

esin is widely used in the medical field and in daily life for gel nail polish and other applications, and has many opportunities to come into direct contact with the human body. On the other hand, many reports of resin allergies, which are side effects, have become a major problem, but the mechanism of onset has not yet been clarified and appropriate treatment methods have not yet been established.
The pathogenesis of resin allergy could not be established, although various conditions were examined. As for the adjuvant effect of resin, in FITC-induced dermatitis, a Th2-type skin inflammation, it showed adjuvant effects in both sensitization and elicitation phases.

Free Research Field

歯科

Academic Significance and Societal Importance of the Research Achievements

レジンは医療現場において歯科治療や人工関節、日常生活においてジェルネイルなどに広く 利用され、直接生体に触れる機会は多い。その一方で、副作用であるレジンアレルギーが多数報告され大きな問題となっているが、未だに発症機序は明らかになっておらず適切な治療法も確立されていない。そのため、本研究成果により、同症の病態解明をめざし、予防法および治療法を提供することを目的とする。