Verification of periodontal disease risk through dietary habits targeting advanced glycation end products

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Asahi University
• Principal Investigator: Azuma Tetsuji 朝日大学, 歯学部, 准教授 (80432649)
• Co-Investigator(Kenkyū-buntansha): 入江 浩一郎 神奈川歯科大学, 歯学部, 准教授 (50509594) ; 友藤 孝明 朝日大学, 歯学部, 教授 (80335629)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 終末糖化産物 / 口腔の健康状態 / 生活習慣

Outline of Final Research Achievements

In this study, we investigated the relationship between the presence or absence of accumulated advanced glycation end products (AGEs), oral health status, and lifestyle habits in a sample of 130 individuals. Participants were classified into groups based on their measured AGEs levels. Oral health status was evaluated by assessing current dental conditions, depth of periodontal pockets, and history of dental caries. Lifestyle habits, including dietary patterns, exercise routines, and sleep quality, were also examined. Logistic regression analysis, using the presence or absence of AGEs accumulation as the dependent variable, revealed a significant association between AGEs accumulation and the number of untreated dental caries (odds ratio = 1.492).

Free Research Field

社会系歯学

Academic Significance and Societal Importance of the Research Achievements

本研究では、口腔の健康状態が終末糖化産物（AGEs）の蓄積に影響を与えることが示唆された。この結果は、口腔の健康が全身の健康にも影響を与える可能性があることを改めて示唆している。さらに、口腔の健康状態が改善されることで、AGEsの蓄積が抑制され、全身の健康維持にも寄与する可能性がある。口腔の健康管理が全身の健康維持にも重要であることを再確認し、健康の保持増進のための包括的なアプローチの重要性を強調する。