2023 Fiscal Year Research-status Report
Exercise, diet and brain training-based cocktail intervention for improving physical and cognitive functions in the elderly
| Project/Area Number |
21K10397
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Hossain Mahbub 山口大学, 大学院医学系研究科, 講師 (80535336)
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| Co-Investigator(Kenkyū-buntansha) |
長谷 亮佑 山口大学, 大学院医学系研究科, 講師 (30711262)
田邉 剛 山口大学, 大学院医学系研究科, 教授 (80260678)
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Keywords | Exercise / Diet / Brain training / Plasma free amino acids / Gut microbiota |
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| Outline of Annual Research Achievements |
Three cohorts of elderly participants, ranging from 75 to 83 years old, have successfully concluded their 18-month interventions. These interventions encompassed a regimen of strength, balance, and endurance training coupled with cognitive function exercises or consumption of 100g of yogurt fortified with arginine and bifidobacterial LKM512 or adherence to their regular lifestyle.
In our comprehensive analysis, we have meticulously examined demographic and clinical variables, as well as crucial biomarkers such as blood polyamines, amyloid-beta, and cognitive function metrics. In line with our findings, we are preparing detailed reports to elucidate their implications. Furthermore, we are actively performing the statistical analysis of additional variables, notably blood metabolomes.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
As planned, we have completed the quantitative measurements of plasma free amino acid concentrations in blood samples collected as different time points using the high-performance liquid chromatography-electrospray ionization-mass spectrometry. Also, shotgun metagenome sequencing of stool samples for gut microbiota collected at baseline and after intervention have been completed.
In accordance with the hypotheses of our study, we are currently engaged in meticulous data analysis to discern potential changes in various variables from baseline to the 6th, 12th, and 18th months of intervention, as applicable. These data are undergoing statistical comparisons both within and between the groups, in line with our research objectives.
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| Strategy for Future Research Activity |
We are in the process of drafting our initial manuscript, which will encapsulate the observed preliminary findings of this study. Subsequently, we will publish our research findings in esteemed, peer-reviewed journals, ensuring that our research contributes meaningfully to the scientific discourse and informs evidence-based practices.
Notably, preliminary findings have already been presented at the BCSIR Congress-2023 in Dhaka, Bangladesh, underscoring the significance and potential impact of our research. Moreover, we are committed to disseminating further results at domestic and international conferences, fostering collaboration and knowledge exchange within the global research community.
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| Causes of Carryover |
To optimize the efficiency of data input and organization and ensure the meticulous management of intricate datasets, we intend to engage an assistant for a specified duration. Allocating resources toward this objective will make our research process smoother and improve the accuracy of our analyses.
Moreover, we are dedicated to disseminating our research findings to the wider scientific community through presentations at both national and international conferences. Travel expenses will be necessary to facilitate this dissemination.
Additionally, we aim to publish our findings in esteemed peer-reviewed journals. Associated publication fees will be essential to support this endeavor.
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