Elucidation of the relationship between the pathogenesis of nonalcoholic fatty liver disease and serum plasminogen activator inhibitor-1 level by large scale survey

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10463
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Hirosaki University
• Principal Investigator: Mikami Kenichiro 弘前大学, 医学研究科, 客員研究員 (00375263)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 非アルコール性脂肪性肝疾患 / PAI-1

Outline of Final Research Achievements

Until 2021, the Iwaki Health Promotion Project health checkup had been canceled due to the coronavirus pandemic, but from 2022, the health checkups have been held again on reduced scales. However, due to delays in data handling, it was not possible to conduct an analysis that included items for diagnosing non-alcoholic fatty liver disease. In 2022, 731 of the health checkup participants were able to have their abdominal ultrasound scans analyzed, of which 273 (37.3%) were found to have fatty liver. There was no difference in blood plasminogen activator inhibitor-1 concentration between participants without fatty liver (28.7 ng/mL) and those with fatty liver (28.4 ng/mL). Body mass index, blood alanine aminotransferase, triglycerides, and hemoglobin A1c were significantly higher in the group of participants with fatty liver.

Free Research Field

消化器内科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、生活習慣などを含む多因子を背景とする非アルコール性脂肪性肝疾患について、2000項目以上の超多項健診ビッグデータを包括して横断的および縦断的に解析することにより、病態解明できる可能性があり非常に学術的意義が高い。また、肥満人口の急増とともに非アルコール性脂肪性肝疾患が増加して社会問題にもなっていることから、病態を解明して新たな予防法・治療法を確立することは社会的意義も非常に大きい。
この度はコロナ禍のため健康増進プロジェクト健診が中止となり、本研究では十分に解析できなかった。現在はコロナウイルスの感染状況が落ち着いてきており、健診が再開され健診データが徐々に利用可能となってきている。