2023 Fiscal Year Final Research Report
Epidemiological study on subjects with sleep disordered breathing with special reference to neuro-vascular biomarkers
| Project/Area Number |
21K10481
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Kawada Tomoyuki 日本医科大学, 大学院医学研究科, 大学院教授 (00224791)
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| Co-Investigator(Kenkyū-buntansha) |
稲垣 弘文 日本医科大学, 医学部, 講師 (50213111)
大塚 俊昭 日本医科大学, 医学部, 准教授 (80339374)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 睡眠障害 / αシヌクレイン / 総アディポネクチン / 高分子量アディポネクチン / 加齢 / 生物学的モニタリング / 睡眠時無呼吸症 / リスクアセスメント |
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| Outline of Final Research Achievements |
Plasma alpha-synuclein, total and high-molecular-weight adiponectin concentrations were measured in occupational male nonsmokers. In addition, subjective information on well-rested through sleep was also used for the analysis. We planned to investigate the relationship between sleep habits and neuro-vascular biomarkers. The geometric mean (geometric SD) of three biomarkers in subjects with good sleep was 12.9 ng/mL (2.04), 5.6 μg/mL (1.69), and 1.7 μg/mL (1.95), respectively. Those with poor sleep were 13.3 ng/mL (2.27), 5.9 μg/mL (1.63), and 1.8 μg/mL (1.83), respectively. There were no significant differences in the mean values between the two groups. Furthermore, no age-related changes were observed in three biomarkers. In the era of COVID-19, there was a difficulty for conducting an intervention research regarding the effect of sleep indicators on neurobiomarker. Physiological monitoring of sleep, including sleep disordered breathing, should be checked by further studies.
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| Free Research Field |
予防医学
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| Academic Significance and Societal Importance of the Research Achievements |
睡眠での休養情報は、客観的（生理的）睡眠指標と並んで、人の長期的健康維持に重要な指標であると考えられる。今回、職域男性非喫煙者の血漿αシヌクレイン、総および高分子量アディポネクチン濃度を測定し、それらが睡眠での休養の可否により違いがあるかどうか、検討した。睡眠休養と各バイオマーカーとの関連性は認められなかった。また、人間ドック受診者のオプション検査として、簡易睡眠時無呼吸検査によるAHI計測と、心臓バイオマーカーである血清NT-proBNPを測定し、その関連性を検討した。今後、生理的睡眠指標を用いて体重およびCPAPの介入研究を行い、睡眠が及ぼす神経・血管代謝への影響を検証したいと考える。
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