Development of Novel Universal Wound Care by Inhibition of "Neutrophil Extracellular Trap" for Chronic Wounds

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10598
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58050:Fundamental of nursing-related
• Research Institution: Tohoku University
• Principal Investigator: Tanno Hiromasa 東北大学, 医学系研究科, 講師 (10755664)
• Co-Investigator(Kenkyū-buntansha): 菅野 恵美 東北大学, 医学系研究科, 教授 (10431595) ; 高木 尚之 東北大学, 医学系研究科, 非常勤講師 (30569471)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 創傷治癒 / 血管新生

Outline of Final Research Achievements

Chronic wounds are intractable due to the combined effects of biofilm formation and impaired blood flow. However, there is no universal wound care that can simultaneously approach multiple causes. In this study, we aimed to establish universal wound care by elucidating the effect of defibrase, which has already been shown to inhibit neutrophil extracellular trapping, on wound healing.
Using acute and chronic wound models, we analyzed the effects of defibrase on wound healing and found that defibrase promotes wound healing by analyzing wound closure rate, re-epithelialization rate, granulation area, and angiogenesis.

Free Research Field

基礎看護学

Academic Significance and Societal Importance of the Research Achievements

慢性創傷を有する患者は、本邦だけでなく、世界的に増加の一途をたどっている。特に糖尿病患者は増加しており、糖尿病性潰瘍の患者の増加も予想される。感染や血流障害などのより、慢性創傷のケアは難渋するが、本研究のより複数の難治化要因に同時にアプローチ可能なユニバーサル創傷ケアを開発することができれば、救済できる慢性創傷患者を増やすことが出来ると考える。