The effect of smoking cessation and antioxidant intake on cervical cancer prevention

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K10749
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58060:Clinical nursing-related
• Research Institution: The University of Shiga Prefecture
• Principal Investigator: Nakagawa Miwa 滋賀県立大学, 人間看護学部, 講師 (80778647)
• Co-Investigator(Kenkyū-buntansha): 小野 あゆみ 滋賀県立大学, 人間看護学部, 講師 (40713558) ; 渡邊 友美子 滋賀県立大学, 人間看護学部, 講師 (50647162) ; 越山 雅文 滋賀県立大学, 人間看護学部, 教授 (50724390) ; 生田 宴里 滋賀県立大学, 人間看護学部, 講師 (90739161)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 子宮頸がん / 喫煙 / 抗酸化栄養素 / ビタミン / 予防

Outline of Final Research Achievements

This study aimed to clarify the differences in antioxidant intake and smoking status between women who were found to have abnormal cervical cytology and whose condition returned to normal during follow-up and those whose lesions persisted and worsened.The subjects were those who had previously had abnormal cervical cytology in a cancer screening test and were followed up at least three times with 3-4 month screenings.The results of investigating their smoking history, including passive smoking, and their intake of antioxidant nutrients showed that in very early lesions (HPV infection to dysplasia), which are precancerous for cervical cancer, smoking or passive smoking patients tended to have delayed healing of lesions compared to non-smoking patients.

Free Research Field

慢性看護学

Academic Significance and Societal Importance of the Research Achievements

子宮頸がんのリスク因子として、ハイリスクHPV感染以外に、ピルの服用、性交渉頻度・パートナー数が多いこと、免疫抑制剤の使用、喫煙などが先行研究であげられており、喫煙に関しては受動喫煙でもリスクがあることがわかっている。しかし、数年をかけて子宮頸がんとなる経過の中で、前がん病変の初期段階における喫煙の影響を調査された研究はなかった。今回の調査にて、子宮頸がんの前がんに当たるごく初期病変（HPV感染～異形成）の段階において、喫煙または受動喫煙患者では、禁煙患者に比べ病変の治癒遅延傾向が示され、子宮頸がん予防において意義ある研究となったと考える。