Age-related changes in skeletal muscle mitochondria stracture and effects of exercise

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K11401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Meiji University
• Principal Investigator: Takeda Kohei 明治大学, 政治経済学部, 専任講師 (00807349)
• Co-Investigator(Kenkyū-buntansha): 武政 徹 筑波大学, 体育系, 教授 (50236501)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 骨格筋 / ミトコンドリア

Outline of Final Research Achievements

In this study, an optical microscopy system was used to investigate the changes in mitochondrial structure in mouse skeletal muscle with aging. The mitochondrial structure within isolated muscle fibers did not change with aging. The localization of proteins related in mitochondrial structure was also examined using frozen sections and was not affected by aging. These results suggest that the mitochondrial structure in skeletal muscle may not change with aging, unlike denervation and hindlimb suspension.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

これまで加齢やサルコペニアによる骨格筋ミトコンドリアに関する研究は、生化学的手法を用いたものが多かった。本研究では、筋線維内のミトコンドリアを直接観察することで、加齢による構造の変化を明らかとしようとした点において学術的意義がある。