2023 Fiscal Year Final Research Report
Establishment of a new sarcopenia treatment using the action of IL-4
| Project/Area Number |
21K11428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小倉 裕司 聖マリアンナ医科大学, 医学部, 講師 (90509952)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | IL-4 / 筋幹細胞 / 細胞融合 / MyoD / Myogenin / Myomerger |
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate the mechanism by which IL-4 induces fusion of muscle stem cells and to determine whether its action can be used to promote muscle regeneration and muscle formation by in vitro and in vivo.
We have shown that IL-4 signaling promotes muscle stem cell fusion through the expression of the muscle stem cell-specific transcriptional regulators MyoD and myogenin and the cell fusion factor myomerger.We also found that IL-4 treatment promotes muscle regeneration during muscle injury in mouse skeletal muscle.
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| Free Research Field |
筋生理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、IL-4シグナルを利用することが筋幹細胞の融合を促進し、筋肉の形成や再生能を効果的に向上させた。この成果をもとに将来的には、IL-4シグナルを標的とした筋肉の肥大や筋肉の再生の促進あるいは筋肉の萎縮を予防のための治療薬への応用に繋がることが期待される。
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