Activation of muscle-sympathetic feedback neural circuits by lactate

2024 Fiscal Year Final Research Report

• Project/Area Number: 21K11461
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: Masuda Hiroyuki 新潟医療福祉大学, 健康科学部, 助教 (10738561)
• Co-Investigator(Kenkyū-buntansha): 八坂 敏一 新潟医療福祉大学, 健康科学部, 教授 (20568365)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Keywords: 骨格筋 / 乳酸 / 交感神経活動

Outline of Final Research Achievements

While lactate has classically been considered as a waste product of anaerobic metabolism and a fatigue reagent, this view has changed radically in recent years. It is now established that even fully aerobic conditions, lactate is the final product of glycolysis in many cell types. Lactate can be secreted, for example, by working muscle. Striated muscle is innervated by multiple classes of sensory neurons. Specialized muscle spindles give rise to slowly conducting group Ⅲ and Ⅳ fibers. These afferents was recently characterized in detail and shown to have endings in the connective tissue layers closely associated with muscle fibers, and were mechanosensitive and metabosensitive. However, the basis of effects of lactate in the nervous system particularly on primary muscle afferents are currently unclear. The purpose of this study was to examine whether how skeletal muscle afferent by lactate promotes muscle sympathetic nerve activity through which neural circuity.

Free Research Field

運動神経生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は、解明が進んでいる局所筋の乳酸代謝と、未解明である乳酸の全身反応を繋ぐ役割があり、また、乳酸の恒常性機構を解明する上での基盤となる研究と位置づけることができる。今後の継続した研究によって、これまで局所筋が対象の中心であったスポーツ科学研究に新しい展開を生み出し、「全身持久力を高めるために効果的なトレーニング処方・運動処方」の開発に応用できる可能性が考えられる。