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2023 Fiscal Year Final Research Report

Role of nitric oxide in venous vascular response during exercise: The study using vegetable-derived nitrate intake

Research Project

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Project/Area Number 21K11561
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59030:Physical education, and physical and health education-related
Research InstitutionToyo University

Principal Investigator

OUE Anna  東洋大学, 健康スポーツ科学部, 教授 (00550104)

Project Period (FY) 2021-04-01 – 2024-03-31
Keywords一酸化窒素活性 / 筋ポンプ作用 / 血圧調節 / 静脈還流 / 静脈血管収縮 / 静脈血管伸展性 / ビートルートジュース
Outline of Final Research Achievements

We investigated whether the enhanced nitric oxide (NO) activity with vegetable-derived nitrate intake influenced the control of venous vascular responses at rest and during exercise. The findings in our study were that the elevation of NO activity with intake of beetroot juice in healthy young adults does not alter 1) venous compliance at rest, 2) sympathetic venoconstriction during exercise and 3) calf venous return by skeletal muscle pump.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は,食品由来の成分を応用して運動時における静脈血管調節に対するNOの役割を解明するものであり,静脈血管の未解決な調節機序を運動と栄養・食品機能性の両側面からアプローチしようとしている点に学術的意義がある.また,野菜由来の硝酸塩摂取に伴うNO活性上昇には血圧を下げる効果もあることから,本研究を通して,NOが静脈血管に果たす役割と降圧効果の関連が明らかになれば,静脈血管調節の観点から新たな循環器系疾患予防や健康寿命延伸のための健康施策考案の一助となりうる点に社会的意義がある.

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Published: 2025-01-30  

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