リアルワールドデータ分析と機械学習による健康寿命延伸/介護予防エビデンスの確立

2023 Fiscal Year Annual Research Report

• Project/Area Number: 21K11569
• Research Institution: Niigata University
• Principal Investigator: 藤原 和哉 新潟大学, 医歯学総合研究科, 特任准教授 (10779341)
• Co-Investigator(Kenkyū-buntansha): 曽根 博仁 新潟大学, 医歯学系, 教授 (30312846) ; 児玉 暁 新潟大学, 医歯学総合研究科, 特任准教授 (50638781)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 医療ビッグデータ / データサイエンス / リアルワールドデータ / 健康寿命延伸 / 寛解

Outline of Annual Research Achievements

今回、95％以上の正確性をもつ独自システムを用いた診療内容の医学的評価を基盤とした手法から、心筋梗塞、心不全、脳卒中、腎透析、下肢切断、失明、骨折、認知症の発生状況を判定する100万人を超えるデータベースの構築に取り組み、一部に関してはデータベース基盤を確立した。そのデータを用い、動脈硬化性疾患のリスク因子の解明を含め、多くの成果を報告した。
さらに糖尿病専門家グループのデータを用い、わが国ではじめて、新たに定義された新国際基準を用いて、糖尿病の寛解に関する大規模な調査と報告を行い、1000人年あたり10.5人（＝年間約1％）が寛解し、①男性、②40歳未満、③糖尿病と診断されてから1年未満、④HbA1c値7.0%未満、⑤BMIが高値、⑥１年間の減量幅が5%以上、⑦薬物療法を受けていない人においては、寛解に至る割合が高く2％以上となり、その中でも、薬物療法を受けていない人、HbA1c値7.0%未満の人、1年間の減量幅が5～9.9％の人、10％以上の人では、1000人年あたりの寛解発生数が、それぞれ21.7人、27.8人、25.0人、48.2人と大きく上昇していたを明らかとした。また、多変量解析の結果において、男性、糖尿病罹患期間が短いこと、観察開始時のHbA1cが低いこと、観察開始時の肥満度（BMI）が高いこと、1年間のBMI変化率（減少）が大きいこと、観察期間開始時に薬物治療を受けていないことが、それぞれ独立して寛解と関連していたことを示した。

Research Products

• [Journal Article] Cross-Sectional and Longitudinal Associations between Forearm Bone Mineral Density and Anthropometry in Adult Japanese Men and Women (2024)
  • Author(s): Ishizawa Masahiro、Fujihara Kazuya、Yachida Junko、Ikeda Izumi、Sato Takaaki、Yamada Takaho、Kobayashi Ayako、Tanaka Shiro、Nakagawa Yoshimi、Matsuzaka Takashi、Shimano Hitoshi、Tashiro Minoru、Kodama Satoru、Kato Kiminori、Sone Hirohito
  • Journal Title: Journal of Bone Metabolism Volume: 31 Pages: 21～30
  • DOI: 10.11005/jbm.2024.31.1.21
• [Journal Article] Association between screen time, including that for smartphones, and overweight/obesity among children in Japan: NICE EVIDENCE Study 4 (2024)
  • Author(s): Ikeda Izumi、Fujihara Kazuya、Morikawa Yoshizawa Sakiko、Takeda Yasunaga、Ishiguro Hajime、Yamada Harada Mayuko、Horikawa Chika、Matsubayashi Yasuhiro、Yamada Takaho、Ogawa Yohei、Sone Hirohito
  • Journal Title: Endocrine Journal Volume: 71 Pages: 171～179
  • DOI: 10.1507/endocrj.EJ23-0343
• [Journal Article] Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of a nationwide patient registry (JDDM73) (2023)
  • Author(s): Fujihara Kazuya、Khin Laymon、Murai Koshiro、Yamazaki Yurie、Tsuruoka Kahori、Yagyuda Noriko、Yamazaki Katsuya、Maegawa Hiroshi、Tanaka Shiro、Kodama Satoru、Sone Hirohito、JDDM Study Group
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 25 Pages: 2227～2235
  • DOI: 10.1111/dom.15100
• [Journal Article] Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of nationwide patient registry in Japan (<scp>JDDM</scp>74) (2023)
  • Author(s): Fujihara Kazuya、Khin Laymon、Murai Koshiro、Yamazaki Yurie、Tsuruoka Kahori、Yagyuda Noriko、Yamazaki Katsuya、Maegawa Hiroshi、Tanaka Shiro、Kodama Satoru、Sone Hirohito、JDDM Study Group
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 25 Pages: 3125～3135
  • DOI: 10.1111/dom.15206
• [Journal Article] Network meta-analysis of glucose-lowering drug treatment regimens with the potential risk of hypoglycemia in patients with type 2 diabetes mellitus in terms of glycemic control and severe hypoglycemia (2023)
  • Author(s): Kodama Satoru、Fujihara Kazuya、Ishiguro Hajime、Matsubayashi Yasuhiro、Kitazawa Masaru、Iwanaga Midori、Yamada Takaho、Kato Kiminori、Nakagawa Yoshimi、Tanaka Shiro、Shimano Hitoshi、Sone Hirohito
  • Journal Title: Journal of Investigative Medicine Volume: 71 Pages: 400～410
  • DOI: 10.1177/10815589221149188
• [Journal Article] Machine Learning Approach to Drug Treatment Strategy for Diabetes Care (2023)
  • Author(s): Fujihara Kazuya、Sone Hirohito
  • Journal Title: Diabetes &amp; Metabolism Journal Volume: 47 Pages: 325～332
  • DOI: 10.4093/dmj.2022.0349
• [Journal Article] Utility of a Physical Fitness Score in Screening for Chronic Diseases (2023)
  • Author(s): Sato Takaaki、Fujihara Kazuya、Yamada Mayuko Harada、Chou Kaori、Yaguchi Yuta、Kitazawa Masaru、Ishiguro Hajime、Osawa Taeko、Yamada Takaho、Kodama Satoru、Kato Kiminori、Sone Hirohito
  • Journal Title: Journal of Sports Science and Medicine Volume: 0 Pages: 98～110
  • DOI: 10.52082/jssm.2023.98
• [Journal Article] Combined effects of blood pressure and glycemic status on risk of heart failure: a population-based study (2023)
  • Author(s): Kobayashi Ayako、Fujihara Kazuya、Yamada Mayuko Harada、Sato Takaaki、Yaguchi Yuta、Kitazawa Masaru、Matsubayashi Yasuhiro、Iwanaga Midori、Yamada Takaho、Kodama Satoru、Sone Hirohito
  • Journal Title: Journal of Hypertension Volume: 41 Pages: 470～475
  • DOI: 10.1097/HJH.0000000000003362
• [Journal Article] Impact of a history of cardiovascular disease and physical activity habits on the incidence of functional disability (2023)
  • Author(s): Kodera Remi、Fujihara Kazuya、Koyama Tetsuya、Shiozaki Haruka、Mutsuma Yurie、Yagyuda Noriko、Hatta Mariko、Tsuruoka Kahori、Takeda Yasunada、Araki Atsushi、Sone Hirohito
  • Journal Title: Scientific Reports Volume: 13 Pages: 20793
  • DOI: 10.1038/s41598-023-47913-z
• [Journal Article] Retrospective cohort study to examine the association between serum amylase and the incidence of type 2 diabetes mellitus, Toranomon Hospital Health Management Center Study 23 (TOPICS 23) (2023)
  • Author(s): Ikeda Izumi、Fujihara Kazuya、Osawa Taeko、Takeda Yasunaga、Hatta Mariko、Matsubayashi Yasuhiro、Kodama Satoru、Mori Yasumichi、Kadowaki Takashi、Honda Ritsuko、Arase Yasuji、Sone Hirohito
  • Journal Title: BMJ Open Diabetes Research &amp; Care Volume: 11 Pages: e003482～e003482
  • DOI: 10.1136/bmjdrc-2023-003482
• [Journal Article] Associations among metabolic health, weight status, and various physical fitness components in Japanese adolescents: a cross-sectional study (NICE EVIDENCE study- Agano 3) (2023)
  • Author(s): Morikawa Sakiko Yoshizawa、Takeda Yasunaga、Fujihara Kazuya、Ikeda Izumi、Kobayashi Ayako、Hatta Mariko、Mitsuma Yurie、Horikawa Chika、Ishiguro Hajime、Yamada Takaho、Ogawa Yohei、Sone Hirohito
  • Journal Title: Journal of Sports Sciences Volume: 41 Pages: 1279～1289
  • DOI: 10.1080/02640414.2023.2268358
• [Presentation] Big data and machine learning applications in diabetes care (2023)
  • Author(s): Fujihara K
  • Organizer: International Congress of Diabetes and Metabolism
  • Int'l Joint Research / Invited
• [Presentation] Real-world Data Applications in Glucose Tolerance Status, Obesity and Cardiovascular Disease (2023)
  • Author(s): Fujihara K
  • Organizer: International Congress on Obesity and MEtabolic Syndrome 2023 (ICOMES 2023)
  • Int'l Joint Research / Invited
• [Presentation] Incidence and predictors of remission and relapse of type 2 diabetes mellitus in Japan: Analysis of Nationwide Patient Registry (2023)
  • Author(s): Fujihara K, Khin L, Murai K, Yamazaki Y, Tsuruoka K, Yagyuda N, Yamazaki K, Maegawa H, Tanaka S, Kodama S, Sone H; JDDM Study Group.
  • Organizer: 83rd American Diabetes Association (ADA) Scientific Sessions
  • Int'l Joint Research
• [Presentation] The conflicting significance of high BMI as a predictor of individual diabetic complications (2023)
  • Author(s): Yaguchi Y, Fujihara K, Kobayashi A, Kimura D, Khin L, Wu S, Ferreira Ed, Sato T, Horikawa C, Matsubayashi Y, Kato K, Sone H
  • Organizer: 83rd American Diabetes Association (ADA) Scientific Sessions
  • Int'l Joint Research
• [Presentation] Assessment of a comprehensive physical fitness index to predict future diabetes mellitus (DM) and metabolic syndrome (MetS) (2023)
  • Author(s): Sato T, Fujihara K , Yamada MH , Cho K , Yaguchi Y, Yamamoto M , Kitazawa M , Ishiguro H , Osawa T, Yamada T , Kato K , Sone H
  • Organizer: 83rd American Diabetes Association (ADA) Scientific Sessions
  • Int'l Joint Research