2023 Fiscal Year Final Research Report
Study on paradox between the trends in nutritional environment and plasma lipid parameters in Japan
| Project/Area Number |
21K11586
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Chubu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
呂 鋭 中部大学, 応用生物学部, 准教授 (80381862)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | HDL / 動脈硬化 / 生活環境 / 疫学 |
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| Outline of Final Research Achievements |
Plasma HDL concentration is an important negative risk factor for atherosclerotic diseases. HDL in the Japanese population is high compared to that internationally, and clarification of its genetic background and public health trends is important to understand the characteristics of the disease structure and its trends in Japan. In this study, we identified Japanese schistosomiasis as a regional accumulator of CETP deficiency, one of the causes of high HDL in East Asia. We also examined in detail the factors contributing to the long-term upward trend of HDL in the Japanese population, an element of which is the marked increase in HDL containing only apo AI (but not apo AII). Paradoxical findings were obtained: regardless of normal lifestyle and nutritional factors, it is associated with a decrease in the ratio of seafood to meat intake.
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| Free Research Field |
脂質代謝学、栄養学
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| Academic Significance and Societal Importance of the Research Achievements |
血漿HDLの公衆衛生学的動向は、その地域の疾病構造やその動向を予測する上で重要な要素の一つである。本研究では、日本人の高HDLの傾向の要因の一つであるCETP欠損症の遺伝子蓄積要因についての知見が前進したことは、他の脂質異常症の遺伝子異常の解析にヒントを与えるものである。また日本人の血漿HDL値が上昇を続けていることが詳細に確認できたことと、その要因に従来知られていたHDL値との関連要因以外の要因が関わっている可能性が示唆された。見かけ上魚介類対肉類の摂取比率との逆説的関連が見られたが、今後、それ以外に未知の環境要因などが絡んでいることなどを、検討してゆく必要がある。
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