Elucidating the role of NAD metabolism in amino acids uptake for the prevention of sarcopenia

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K11593
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: University of Toyama
• Principal Investigator: Yaku Keisuke 富山大学, 学術研究部医学系, 助教 (70761865)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: NAD代謝 / サルコペニア

Outline of Final Research Achievements

In this study, we investigated the effect of NAD supplementation on the improvement of muscle function, aiming at the prevention and treatment of sarcopenia. Furthermore, we analyzed the pathway through which NAD precursors are utilized for NAD synthesis in muscle. We found that NAD precursors improved muscle function in mice whose muscle NAD levels are decreased. Additionally, the efficiency of NAD repletion was greater with intravenous administration than that with oral administration. Furthermore, we found that the microbiota is associated with NAD metabolism in both oral and intravenous administration of NAD precursors.

Free Research Field

栄養生化学

Academic Significance and Societal Importance of the Research Achievements

NRやNMNを用いたNAD補充は抗老化分野で世界的に注目されており、これらを用いた臨床試験が盛んに行われている。また、これらのサプリメントはサプリメントとして一般的にも用いられている。本研究では、NAD代謝の新たな側面として、NRとNMNがいずれも腸内細菌の影響を受けること、また投与経路によって利用効率の差が認められることを明らかにした。これらの知見はNAD代謝を標的とした健康増進において非常に重要な知見である。