The effect of renin-angiotensin system in mentenance of skeltal muscle and diseases

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K11624
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Ehime University
• Principal Investigator: Iwanami Jun 愛媛大学, 医学系研究科, 准教授 (90624792)
• Co-Investigator(Kenkyū-buntansha): 金川 基 愛媛大学, 医学系研究科, 教授 (00448044)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: レニン・アンジオテンシン系 / AT2受容体 / 筋再生

Outline of Final Research Achievements

Accumulating evidences and previous our research suggest that angiotensin II type 2 (AT2) receptor stimulation could contribute to protection against tissue damage. However the effect of AT2 receptor on muscle disease is still unclear. Therefore, we investigated the effect of AT2 receptor on muscle regeneration in a cardiotoxin (CTX)-induced skeletal muscle injury mouse model. Five days after CTX treatment, muscle regeneration was deleyed in AT2 receptor deficient mice compared with wild type mice. However, in long term injury, the reduction in muscle fiber size was suppressed in AT2 receptor deficient mice. These results suggest that AT2 receptor enhance muscle regeneration in early stage of muscle injury, but are delayed in the long term.

Free Research Field

生化学

Academic Significance and Societal Importance of the Research Achievements

組織保護作用を持つことが報告されているAT2受容体だが、骨格筋への影響についての研究・報告はほとんどない。本研究では、AT2受容体が筋傷害後の再生に影響していることを明らかにした。超高齢化社会となった本邦では、骨格筋の維持が健康寿命に深くかかわっており、怪我やサルコペニアといった筋疾患の予防・治療に寄与する研究であると考えられる。