2023 Fiscal Year Final Research Report
Establishment of dietary environment for regulation of higher brain function via control of protein metabolism
| Project/Area Number |
21K11628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | The University of Shiga Prefecture |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | アミノ酸 / 脳神経科学 / 代謝 |
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| Outline of Final Research Achievements |
We investigated the effects of intermittent fasting and hormone-induced hypermetabolism on brain kynurenic acid production and peripheral tryptophan metabolism. Intermittent fasting lowered brain kynurenic acid levels and peripheral tryptophan catabolism. Furthermore, intermittent fasting suppressed high tryptophan diet-induced brain kynurenic acid production and peripheral tryptophan hypermetablosim. Thyroxine administration enhanced liver tryptophan catabolism but not brain kynurenic acid levels. These results showed that suppression of peripheral tryptophan catabolism and enhancement of liver tryptophan catabolism suppressed increase of brain kynurenic acid production, and thus suggest that control of protein metabolism can protect higher brain function.
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| Free Research Field |
栄養学および健康科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は，末梢の代謝変動が高次脳機能に影響をおよぼす可能性を示すものであり，栄養学と脳神経科学を融合した新たな研究領域を開拓・展開するものである．食事や運動などの生活習慣によって末梢の代謝変動を調節することにより，脳神経疾患の発症予防，高次脳機能低下の予防・軽減につながる．さらには，高齢者の認知機能低下の予防・軽減に貢献するという社会的意義をもつ．
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