2023 Fiscal Year Final Research Report
Oligodendrocyte progenitor cells in the hypothalamus play a role in feeding
| Project/Area Number |
21K11659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
長谷 都 聖マリアンナ医科大学, 医学部, 准教授 (20450611)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | オリゴデンドロサイト前駆細胞 / 視床下部 / PDGFRα |
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| Outline of Final Research Achievements |
Most PDGFRα-immunoreactive cells in the brain are also NG2 positive and these cells are termed oligodendrocyte progenitor cells (OPCs). It is suggested that OPCs are not only differentiated to cells formed myelin sheath but also developed to functional neurons. However, precise physiological role of OPCs are not well documented. Previously, we suggested PDGFRα as a fasting-induced gene in the hypothalamus by means of expression array. Indeed, it was reported that NG2 cells in the median eminence were involved in body weight control. So, we hypothesized that PDGFRα-mediated signals in the hypothalamus were involved in metabolic control under physiological condition. We showed that PDGFRα protein in the hypothalamus was induced by fasting under chow feeding but this induction was impaired under high fat diet feeding which caused obesity. This result lead us to think that PDGFRα plays not only a physiological but also a pathological role in feeding control.
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| Free Research Field |
生理学
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| Academic Significance and Societal Importance of the Research Achievements |
オリゴデンドロサイト前駆細胞 （Oligodendrocyte Precursor Cell, OPC）は中枢神経系の髄鞘を形成するオリゴデンドロサイトの前駆細胞であるが、中枢神経系に豊富に存在しており、近年はそれ以外にも多様な機能のあることが想定されている。我々は、摂食の調節にも視床下部のOPCが関与している可能性を見出した。OPCが摂食を調節する新たなプレーヤーとなるならば、それをターゲットとして、新たな抗肥満薬の開発に貢献することも可能となると期待している。
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