2024 Fiscal Year Final Research Report
Development of cancer risk score based on oxidative stress and examination of its validity
| Project/Area Number |
21K11679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Saga University |
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Principal Investigator |
Hara Megumi 佐賀大学, 医学部, 教授 (90336115)
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| Co-Investigator(Kenkyū-buntansha) |
松本 明子 佐賀大学, 医学部, 准教授 (10330979)
南里 妃名子 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 室長 (20612435)
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| Project Period (FY) |
2021-04-01 – 2025-03-31
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| Keywords | 酸化ストレス / 抗酸化 / がん / コーホート研究 |
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| Outline of Final Research Achievements |
This prospective cohort study followed approximately 10,000 Japanese residents over 10 years to investigate the relationship between oxidative stress biomarkers, dROMs, BAP, and their ratio (dROMs/BAP) and cancer incidence. The results showed that higher levels of dROMs and dROMs/BAP were significantly associated with increased risk of cancer, particularly colorectal cancer. A oxidative stress-based cancer risk score, derived from factors such as smoking, alcohol intake, BMI, and diet, also predicted cancer risk effectively. In contrast, urinary 8-OHdG showed no significant association. These findings suggest that serum oxidative stress markers and lifestyle-based scores may serve as practical tools for cancer risk prediction and prevention strategies.
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| Free Research Field |
疫学、予防医学、公衆衛生学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、酸化ストレス指標（dROMs、BAP、dROMs/BAP比）とがんの罹患リスクを日本人コホートで初めて示した。特に、dROMs/BAP比の上昇が結腸がんリスクを約1.5倍に高めるという結果は、酸化ストレスが部位特異的にがん発症に関与する可能性を示唆しており、がん予測指標の選定において重要な示唆を与える。また、調査票ベースで算出可能な酸化ストレスに基づくがん罹患リスクスコアは、地域住民を対象とした健康教育や予防介入において実用性が高く、がんの早期発見や予防戦略の強化に貢献する可能性がある。今後の介入研究や他地域での再現性検証を通じて、より広範な公衆衛生施策への応用が期待される。
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