2023 Fiscal Year Final Research Report
Analysis of the metabolic pathways of monounsaturated fatty acids from fruits in cultured cells.
Project/Area Number |
21K11702
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Osaka Metropolitan University (2022-2023) Osaka Prefecture University (2021) |
Principal Investigator |
Iwaki Toshio 大阪公立大学, 大学院生活科学研究科, 准教授 (20295728)
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Co-Investigator(Kenkyū-buntansha) |
乾 博 大阪公立大学, 生命環境科学研究科, 客員研究員 (20193568)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Keywords | 一価不飽和脂肪酸 / cis-バクセン酸 / オレイン酸 / GC |
Outline of Final Research Achievements |
Obesity and lifestyle diseases pose a growing health concern, highlighting the need for research on lipid nutrition to improve treatment and prevention. While the benefits of polyunsaturated fatty acids (PUFAs) like EPA and DHA are well-established, the physiological roles of monounsaturated fatty acids (MUFAs) abundant in fruits, particularly nuts, remain unclear. This study investigated the metabolic fate of fruit-derived MUFAs in animal cells. We found these MUFAs were incorporated into the cell membrane fraction and underwent metabolic processes, including chain elongation. These findings suggest fruit-derived MUFAs may exert novel physiological effects, warranting further investigation.
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Free Research Field |
脂質栄養学
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Academic Significance and Societal Importance of the Research Achievements |
現代社会における肥満や生活習慣病の増加は、深刻な健康課題であり、その治療と予防は喫緊の課題であり,脂質栄養学的な研究が重要となっている。本研究では、果実由来の一価不飽和脂肪酸の細胞内代謝動態を明らかにし、新規生理作用の可能性を示唆した。すなわち,血液を含め身体を構成する細胞に本来含まれない果実由来の一価不飽和脂肪酸が,食事を通して細胞内に取り込まれ,細胞の生理作用に影響を与える可能性が見出された。今後、更なる研究を通して、これら脂肪酸の具体的な作用機序を解明し、食事内容による健康増進への応用可能性を検討していく必要があると考える。
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