2023 Fiscal Year Final Research Report

Organ specificity in the variation of lipid metabolism by fructose and fatty acids

Research Project

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Project/Area Number	21K11711
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Kindai University
Principal Investigator	Kishida Kunihiro 近畿大学, 生物理工学部, 准教授 (30412703)
Co-Investigator(Kenkyū-buntansha)	井原勇人和歌山県立医科大学, 共同利用施設, 准教授 (00223298) 永井宏平近畿大学, 生物理工学部, 准教授 (70500578)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	フルクトース / 脂肪酸 / 脂質代謝 / 肝臓 / 腸間膜脂肪 / 小腸
Outline of Final Research Achievements	In order to clarify organ-specific differences in metabolic changes induced by the simultaneous ingestion of fructose and fatty acids, studies were conducted with particular focus on the liver, mesenteric fat, and small intestine. The fructose-induced increase in fatty acid biosynthesis-related gene expression was observed in the liver regardless of the type of fat ingested at the same time, whereas in mesenteric fat the increase was more pronounced for glucose. Fructose induced protein expression in the small intestine related to fructose transport and metabolism, such as GLUT5, G6Pase, and F1,6BPase, regardless of the type of fat or oil. The results also suggest that simultaneous consumption of fructose and fish oil may modulate fatty acid oxidation and peroxidation in the small intestine.
Free Research Field	食品栄養学
Academic Significance and Societal Importance of the Research Achievements	清涼飲料水を由来とするフルクトースの多量摂取や欧米型の食事に多く含まれる動物性油脂を由来とする飽和脂肪酸の摂取が、肥満やメタボリックシンドローム誘発の原因のひとつである。しかし、食品には飽和脂肪酸だけでなく、さまざまな脂肪酸が含まれ、油脂の種類により生理作用はさまざまである。フルクトースと脂肪酸の同時摂取は、それぞれの生理作用が相加的に現れる臓器もあれば、予想外の影響が発現する臓器もある。本研究は、日常的に摂取するこれらの食品成分が与える影響について、肝臓、内臓脂肪である腸間膜脂肪、小腸に焦点を当て、臓器による作用の違いを明らかにした。