Development of a method on the estimation of composition and toxicity of chlorinated paraffins for elucidating their environmental behavior

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12285
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 64010:Environmental load and risk assessment-related
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Hanari Nobuyasu 国立研究開発法人産業技術総合研究所, 計量標準総合センター, 研究グループ長 (10392648)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 塩素化パラフィン / 成分組成 / 二次元ガスクロマトグラフ / 毒性推定

Outline of Final Research Achievements

In order to elucidate the environmental behavior of chlorinated paraffins (CP), which are substances subject to the Stockholm Convention on Persistent Organic Pollutants, especially their toxic effects, we attempted to analyze CP isomers/homologs before and after a light fastness test using a two-dimensional gas chromatograph mass spectrometer. Unfortunately, we were unable to confirm any dramatic changes in the CP pattern after the test, but we were able to understand the results of a separate test to determine the acute immobilisation on aquatic organisms, which allowed us to develop a part of a method to visualize risk components of CP homologs and isomers. From these results, we believe that we have gained new knowledge about the CP risk profile, which has many unknown aspects, but further verification is required to map the CP composition and risk assessment.

Free Research Field

環境化学

Academic Significance and Societal Importance of the Research Achievements

光耐性の強い強毒性の塩素化パラフィン（CP）を実験的に生成させることは、同じ残留性有機汚染物質（POPs）である塩素化ナフタレンよりも困難だったことから、CPの光耐性が通常のPOPsよりも強いことが判明したこと、二次元ガスクロマトグラフ質量分析計でのCP溶出位置と水-オクタノール分配係数との関連性から水生生物へのリスク評価を把握する一端となる成果を得ることができたこと、また水生生物への遊泳阻害試験から、供した標準物質であるCPのリスク影響を明らかにできたことが挙げられる。