Development of new diagnostic methods for respiratory diseases based on the mechanics of respiratory dynamics

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12637
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Kijima Takashi 兵庫医科大学, 医学部, 教授 (90372614)
• Co-Investigator(Kenkyū-buntansha): 柴田 英輔 兵庫医科大学, 医学部, 助教 (00774613) ; 間瀬 教史 甲南女子大学, 看護リハビリテーション学部, 教授 (40454730) ; 祢木 芳樹 兵庫医科大学, 医学部, 助教 (70814515)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 肺コンプライアンス / IPV / 食道カテーテル / 口腔内圧 / 食道内圧 / 胸腔内圧 / 気道抵抗

Outline of Final Research Achievements

Lung compliance is an index of the lung ditensibility and defined as a ratio of ventilated volume to the intrapulmonary pressure change (L/cmH2O), and is important in the differential diagnosis of respiratory diseases. However, lung compliance has never been clinically measured because we have to measure the intrathoracic pressure using the esophageal balloon catheter method to calculate it, which is not only a highly invasive method but also obtained data are highly variable. We have developed a novel non-invasive method of measurement of lung compliance by the use of intrapulmonary percussive ventilator (IPV), where the intrapulmonary pressure change can be estimated by the amount of change in the intra-oral pressure. Collection of data from patients with various chronic respiratory diseases is currently in progress.

Free Research Field

生体医工学関連

Academic Significance and Societal Importance of the Research Achievements

非侵襲的かつ短時間でのIPV法を用いた肺コンプライアンス計測が臨床応用されれば、各種慢性呼吸器疾患における呼吸機能異常の生理学的病態理解のみならず、症例ごとに最も適切な治療法の提案、治療効果のフォローが可能となり、呼吸生理学の発展と個別化医療の実現に貢献できる。