2023 Fiscal Year Final Research Report
2D eyelids pressure measuring system using sucrose coated contact lenses
| Project/Area Number |
21K12663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Keywords | 眼瞼圧分布測定 / 擦過試験 / スクロース膜 / コンタクトレンズ / 画像計測システム |
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| Outline of Final Research Achievements |
In this study, we proposed a measurement system that measures the two-dimensional distribution of eyelid pressure on the eyeball, for which no measurement method existed until now, using a contact lens coated with a sugar sucrose film and an image processing system. Using a testing device, we clarified the effects of pressure and frequency on sucrose film thickness reduction, and obtained a calibration curve for film thickness reduction and eyelid pressure. We also established a method of casting lenses using precision molds, and developed a method of bonding them to contact lenses using water droplets. The measurement principle and safety were verified through animal experiments using rabbits, and the measurement principle and biological safety proposed by this method were confirmed.
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| Free Research Field |
生体医工学関連
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| Academic Significance and Societal Importance of the Research Achievements |
眼科などでの角膜障害にかかわる疾患は，コロナ下でのPC作業や社会のDX化により罹患率が増える傾向にある．従来，角膜上の傷はフルオロセインなどの色素を点眼することにより診断可能であったが，眼瞼圧との関連は不明であった．またMEMSセンサなども存在したが，1点のみの測定や眼圧測定を行うものであった．本研究では眼球上の眼瞼圧を短時間で2次元的に測定する手法について動物実験まで含めて実験的に検証したものであり，将来的な医療機器開発の基礎資料として意味を持つ．
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