Development of micro-porous titanium scaffold for equipping antibacterial functions and promoting neointimal growths

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12666
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: The University of Tokushima
• Principal Investigator: SEKINE Kazumitsu 徳島大学, 大学院医歯薬学研究部(歯学域), 准教授 (50447182)
• Co-Investigator(Kenkyū-buntansha): 浜田 賢一 徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (00301317)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: スキャフォールド / チタン / 血液接触表面

Outline of Final Research Achievements

To developing chitosan-urethane-like surface modification for Titanium(Ti) with the cell adhesion and the anti-bacterial effect, we studied fundamental coating process with chitosan and collagen onto the Ti, and then evaluated.
Ti specimens were treated firstly hydroxylation treatment and isocyanate treatment with various concentration of collagen, citrate and chitosan mixture. Treated specimens were evaluated with hydrophilic study, optical study, X-ray study, and cell cytotoxicity and cell compatibility. Our results indicated that chitosan-urethane like surface modification showed fine hydrophilicity, good cell adhesion and compatibility compared to bulk Ti material, and exact chitosan modification onto the surface of Ti with thin layered composite that were garanteed with optical analysis and X-ray analysis and observation.

Free Research Field

生体材料工学

Academic Significance and Societal Importance of the Research Achievements

本課題の目的は，近年で広く普及した補助人工心臓の術後における血液接触表面における血栓形成や感染症に対する要素技術である。侵襲度の高い循環器系手術において，術後の血液塞栓症や感染症に対する対策は主に薬剤投与や術後ケアになるが，根元にあるのは人工材料上への血栓形成や細菌付着能にある。本課題はそのような術後リスクに対し，循環器系デバイスで広く使用されるチタンの表面修飾法を提案することで，血栓形成を低減するための自己血管内皮の誘導，またデバイス上への細菌付着の低減を主眼にしており，今後もさらに普及が想定される人工心臓等の循環器系チタンデバイスへ広く使用される事に意義があると考えている。