Development of a powerful bone-fixing polymer-coated screw by applying a novel surface modification technology

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12671
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Ushiku Chikara 東京慈恵会医科大学, 医学部, 講師 (10338874)
• Co-Investigator(Kenkyū-buntansha): 田中 賢 九州大学, 先導物質化学研究所, 教授 (00322850) ; 穴田 貴久 九州大学, 先導物質化学研究所, 准教授 (30398466)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 中間水コンセプト / osseointegration / 高分子 / ポリ(2-メトキシエチルアクリレート；PMEA） / 皮質骨多孔化

Outline of Final Research Achievements

In this study, the osseointegration of the PMEA-modified titanium implant was verified in vivo. The results of mechanical tests (push-in test) and histological bone morphometry (gap width between the implant and cortical bone, cortical bone porosity area/cortical bone area) showed that PMEA suppressed bone resorption around the bone pits, minimizing cortical bone resorption around the implant immediately after placement of the implants, and that the bone formation that occurred at the same time minimized cortical bone resorption between the implant and the pits, and that the bone resorption around the implant was reduced by PMEA. The resulting bone formation narrowed the gap between the round bar and cortical bone surface, and mechanical bone connectivity was enhanced at an early stage.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

本研究グループが確立した中間水コンセプトに基づき開発された表面改質技術は、生体適合性を有し、簡便に低コストで種々の材料表面への修飾に応用することができる。本研究では、PMEA修飾チタン製インプラントが骨固着性(osseointegration)を促進することを、in vivoで確かめた。骨粗鬆症を背景とした骨関連手術の成功のために、骨固着性(osseointegration)を早く確実に獲得できるインプラント開発が望まれるが、PMEA修飾インプラントはその期待に応える実現性が高い技術である。