Application to central venous access port using Soft Tissue-Adhesive Titanium

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Kobe University
• Principal Investigator: Yanagimoto Hiroaki 神戸大学, 医学研究科, 特命教授 (60434833)
• Co-Investigator(Kenkyū-buntansha): 松本 卓也 岡山大学, 医歯薬学域, 教授 (40324793)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 新規生体軟組織用接着材 / 医療機器

Outline of Final Research Achievements

As a new soft tissue adhesive material, an improvement in adhesive strength was achieved by the acid treated titanium thin film. A central venous(CV) port + titanium thin film composite was fabricated and in vivo fascia fixation experiments were conducted using small animals. Actual retention of fascia fixation was attempted using materials with different conditions, such as titanium adhesive mesh diameter, porosity, and calcium phosphate fusion thickness. However, it was found that the CV port + titanium thin-film composite did not adhere due to the high water content around the fascia of small animals. Hydroxyapatite was subsequently investigated as a new bio adhesive material. It was found to have extremely high adhesive strength compared to the titanium thin film and was also able to adhere to intraperitoneal organs. In vivo studies on small animals also showed that it could adhere to intraperitoneal organs. The results will be investigated for clinical application in the future.

Free Research Field

外科領域

Academic Significance and Societal Importance of the Research Achievements

本研究では新規生体軟組織用接着材の２つの候補に関して次の結果が得られた。①チタン薄膜への酸処理方法を改良することによる接着力の向上が認められたこと。②ハイドロキシアパタイトを用いた生体接着剤が内臓臓器への接着力が認められたこと。これらの結果はともに新規の発見であり、今後体内埋め込みデバイスの固定や手術における臓器組織の圧排など外科処置・手術の応用利用に寄与することが期待される。