Elucidation of polymer structure-biocompatibility relationship using model polymers with controlled side-chain sequences

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12687
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Kyushu University
• Principal Investigator: Kobayashi Shingo 九州大学, 先導物質化学研究所, 特任准教授 (70625110)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 精密重合 / 定序性高分子 / regio選択的重合 / Grubbs触媒 / 開環メタセシス重合 / 血液適合性材料 / バイオマテリアル

Outline of Final Research Achievements

Novel polyolefins with controlled side-chain arrangements were synthesized, and the structure-function correlation was investigated to elucidate the mechanism of biocompatibility. Additionally, their potential application as anti-thrombogenic coating materials was explored. Five polymers with flexible polyethylene backbones and eight polymers with rigid cycloolefin polymer backbones were successfully synthesized. In both main chain structures, the polymers exhibited antithrombotic properties comparable to PMEA and demonstrated superior coating film stability. Solid-state NMR evaluations showed that polymers in which the polymer and water were more homogeneously miscible at biological temperatures exhibited higher antithrombotic properties.
The obtained polymers were found to be useful as surface coating materials for extracorporeal membrane oxygenation (ECMO) devices.

Free Research Field

高分子化学

Academic Significance and Societal Importance of the Research Achievements

高分子材料が発現する生体適合性を制御するためには、高分子材料ー生体間相互作用の詳細を解明する必要がある。側鎖配列が制御された新規ポリオレフィンの構造－機能相関に関する本研究成果から、生体適合性高分子に必要な構造的・物性的特徴について理解を深めることができた。本研究で得たポリオレフィン系高分子は、疎水性が極めて高いにも関わらず高い抗血栓性を示し、優れた膜安定性をも示す。本研究成果は、従来の親水性・水溶性高分子に代わる新たな生体適合性材料の設計指針を示すものであり、その応用が期待されるとともに、医療分野における新しいバイオマテリアルの設計や医療デバイス開発、組織工学の進展に寄与することができる。