2023 Fiscal Year Final Research Report
Molecular imaging using meglumine-gadopentetate-glucose solution and 7T-MRI-PCCT
| Project/Area Number |
21K12713
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 90130:Medical systems-related
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2021-04-01 – 2024-03-31
|
| Keywords | 7T-MRI / meglumine-gadopentetate / gadobutrol-glucose / molecular imaging / long visualizing / photon counting / PCCT / enhanced K-edge CT |
|---|
| Outline of Final Research Achievements |
Using vein infusion of linear-chelate meglumine-gadopentetate-glucose solution from a rabbit ear, 7T-MRI and T1WI, whole cancerous regions in a rabbit were observed with a high contrast and spatial resolutions of 0.5 mm. In our research, meglumine-gadopentetate molecules were absorbed into cancerous region along with glucose molecules. Using cyclic-chelate gadobutrol solution, the same results were obtained. Subsequently, we built a PCCT scanner using a CdTe FPD and performed K-edge CT with spatial resolutions of 0.08mm using gadolinium and iodine contrast media. In combination with 7T-MRI, PCCT can be applied to molecular imaging for cancer diagnosis.
|
| Free Research Field |
molecular imaging
|
| Academic Significance and Societal Importance of the Research Achievements |
We performed 7T-MRI using meglumine-gadopentetate-glucose and gadobutrol-glucose solutions to observe whole cancer including hypoxic regions. Furthermore, PCCT using a CdTe FPD is useful for performing enhanced K-edge CT, and multimodal molecular imaging can also be carried out.
|
