2023 Fiscal Year Final Research Report

Development of a new non-invasive intra-renal pelvis pressure measurement based on non-destructive engineering techniques.

Research Project

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Project/Area Number	21K12728
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 90130:Medical systems-related
Research Institution	Ehime University
Principal Investigator	Nishimura Kenichi 愛媛大学, 医学部附属病院, 助教 (20868666)
Co-Investigator(Kenkyū-buntansha)	雑賀隆史愛媛大学, 医学系研究科, 教授 (10314676) 中畑和之愛媛大学, 理工学研究科(工学系), 教授 (20380256) 菊川忠彦愛媛大学, 医学部附属病院, 准教授 (70444734)
Project Period (FY)	2021-04-01 – 2024-03-31
Keywords	腎盂内圧測定 / 生体膜 / 水腎症
Outline of Final Research Achievements	Measurements of waves propagating through a biomembrane (porcine renal pelvis wall) and analysis of wave characteristics due to changes in stress (pressure). And, the renal pelvis pressure is measured by ultrasound. In this study, a single array probe was used to measure the waves in the biomembrane. We confirmed that the thickness and hardness of the biomembrane changed as the stress was varied. It was suggested that the thickness and hardness were involved in the cause of the waveform variation.　At the same time, the propagating wave was measured using a double array probe. The biological membrane is so small that it is difficult to measure only the incident wave, the reflected wave, and the propagating wave, which interfere with each other.　 Currently, we are using a single array probe to measure changes in reflected waves when stress is applied to the biomembrane, and searching for the characteristics of individual waves.
Free Research Field	泌尿器科
Academic Significance and Societal Importance of the Research Achievements	金属等のハードマターに対して，ガイド波伝搬の研究は数多くなされており，これらは非破壊検査等に応用されている。しかし，軟組織に対してガイド波の伝搬に関する研究は，申請者の調べたところ殆ど無かった。本研究ではガイド波からエラストグラフィの原理を用いて，弾性パラメータが測定できる可能性が示唆された。本研究が初めてガイド波を用い非侵襲的に腎盂内圧を測定する基礎研究となる。本理論が立証できれば，腎盂内圧のみならず，肝のう胞や膵のう胞など他疾患の嚢胞圧を測定し嚢胞の進展についての病態の解明につながると考える。