Research on Paper-Based analytical Chip for Blood Viscosity Using micro PADs Technology

2023 Fiscal Year Final Research Report

• Project/Area Number: 21K12729
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Kyushu Institute of Technology
• Principal Investigator: Kenji Sakamoto 九州工業大学, 大学院情報工学研究院, 准教授 (10379290)
• Co-Investigator(Kenkyū-buntansha): 小林 孝一朗 大島商船高等専門学校, 商船学科, 准教授 (10781776)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Keywords: 紙媒体マイクロ流体チップ / microTAS / microPADs / 血液物性値測定 / ヘルスケア

Outline of Final Research Achievements

With the aim of preventing lifestyle-related diseases, which are a major cause of increased medical costs, we conducted research on a paper media test chip for trace amounts of blood (μPADs test chip) that can easily measure the electrical conductivity and viscosity of blood and plasma, which are risk assessment indicators for such diseases.
Through this study, we succeeded in fabricating a paper media chip for measuring electrical conductivity that can be measured with a microvolume sample of approximately 25 μL. Taking advantage of the characteristics of paper media, sample transfer by capillary action and quantitative electrical sensing by flow path and comb microelectrode formation are realized. The paper media chip obtained in the research was used to validate the electrical conductivity measurement of basic chemicals, and the feasibility of measurement with human blood samples was evaluated.

Free Research Field

マイクロ流体工学

Academic Significance and Societal Importance of the Research Achievements

紙媒体マイクロ流体チップの研究において、流路形成プロセス、電極形成プロセス、電気伝導率測定方法の構築を行った、これは、既存の紙媒体マイクロ流体チップとは異なる新規な手法により達成できた。
また得られた紙媒体チップより、基礎化学薬品の電気伝導率測定を実施することが出来たため、安価な電気伝導率測定チップの提案を行う事ができた。またヒト血液サンプルでも電気伝導率の測定を行う事が出来たため、ヘルスケア向けの体液検査チップの可能性を示すことが出来た。